Nerve protein linked to learning and memory
- Nov 01, 2011
Can the nerve signaling inhibitor tomosyn help retain long-term memory? A new study by two University of Illinois at Chicago biologists points to the link.
Findings by Janet Richmond and David Featherstone, both professors of biological sciences at UIC, are reported in the Oct. 31 online early edition of the Proceedings of the National Academy of Sciences.
“This is the first really comprehensive effort to look at the role of tomosyn in fly learning,” said Richmond, who until now studied the protein in an even simpler organism, the lowly nematode, or roundworm.
Several studies have shown that learning behavior in fruit flies requires many of the same proteins used in higher animals, including mammals.
The UIC biologists found that tomosyn plays an important role in regulating the amount of neurotransmitter in the synapse, the junction where messages are relayed between nerve cells. Tomosyn can limit this signaling; eliminating tomosyn strengthens the signaling.
“When synapses get stronger, we learn. When they get weaker, we forget,” said Featherstone. “We discovered that tomosyn is a mechanism that can control whether synapses get stronger or weaker, and this seems to be important for memory formation.”
Tomosyn interacts with a group of proteins known by the acronym SNARE, and that interaction is in turn regulated by an enzyme called PKA, which has been shown to be important for learning.
Knowing this, Richmond and Featherstone ran experiments on fruit flies to see whether tomosyn might play a role in learning and memory.
Their experiments involved the fly’s ability to learn to associate a particular odor with an Electrical shock. Flies remember the association and will avoid the odor for hours afterwards. But by knocking out tomosyn, “the flies were unable to retain that memory,” said Richmond.
The UIC biologists demonstrated how tomosyn can affect both synaptic signaling and learning and memory.
Richmond and Featherstone hope their findings will provide valuable clues that pharmacologists might use in creating new drug therapies for various forms of human memory loss. Richmond said tomosyn is a good protein to experiment with.
“Tomosyn regulates the way synapses work, but it’s not essential for life,” she said. “We hope that by understanding how it functions in memory formation, our research will provide useful insights that may help us better address the issue of severe memory loss.”
Other co-authors include Martin Schwärzel and Antje Richlitzki, researchers specializing in fly learning behavior at the Free University of Berlin’s Institute for Biology/Genetics. Richmond and Featherstone established a collaboration with the Berlin researchers while in Germany on Humboldt Research Awards. Kaiyun Chen, a former UIC research assistant professor in the Featherstone laboratory, served as the electro-physiologist for the study.
University of Illinois at Chicago
Also in this section
- Self-reported sleep disturbances are linked to higher risk for Alzheimer’s disease in men
- New research on walnuts and the fight against Alzheimer’s disease
- Design of micro and nanoparticles to improve treatments for Alzheimers and Parkinsons
- Cold sore virus increases the risk of dementia
- Protein that Causes Frontotemporal Dementia also Implicated in Alzheimer’s Disease
- Mayo researchers reveal pathway that contributes to Alzheimer’s disease
- Brain may ‘work around’ early Alzheimer’s damage
- ‘Disease in a dish’ approach could aid Huntington’s disease discovery efforts
- Why HIV patients develop dementia
- Marijuana compound may offer treatment for Alzheimers disease
- Alzheimer’s disease: are we close to finding a cure?
- Research underway to create pomegranate drug to stem Alzheimer’s and Parkinson’s
Post a comment [ + Comment here + ]
There are no comments for this entry yet. [ + Comment here + ]
Comments are moderated by our editors, so there may be a delay between submission and publication of your comment. Offensive or abusive comments will not be published.