Site updated at Wednesday, 22 June 2016

Living with Dementia

No link between anesthesia, dementia in elderly, Mayo Clinic Study finds

  • - Dementia News
  • May 01, 2013
  • Comments
  • Viewed: 4491
Tags: | alzheimer's disease | dementia in elderly | developing dementia | general anesthesia |

Elderly patients who receive anesthesia are no more likely to develop long-term dementia or Alzheimer’s disease than other seniors, according to new Mayo Clinic research. The study analyzed thousands of patients using the Rochester Epidemiology Project - which allows researchers access to medical records of nearly all residents of Olmsted County, Minn. - and found that receiving general anesthesia for procedures after age 45 is not a risk factor for developing dementia. The findings were published Wednesday, May 1, online in Mayo Clinic Proceedings.

Researchers know that some elderly patients have problems with cognitive function for weeks, sometimes months, following surgical procedures, says senior author David Warner, M.D., a pediatric anesthesiologist at the Mayo Clinic Children’s Center.

There has been concern that exposure to anesthesia may be associated with long-term cognitive changes including dementia, he says. The concern stems in part from a series of studies in which animals were exposed to anesthesia and lesions similar to those observed in Alzheimer’s disease appeared in the brain - including accumulation of amyloid, a protein associated with Alzheimer’s disease.

“It’s reassuring we’re adding to the body of knowledge that there is not an association of anesthesia and surgery with Alzheimer’s,” Dr. Warner says. “There are a lot of things to worry about when an elderly person has surgery, but it seems that developing Alzheimer’s isn’t one of them.”

Researchers studied about 900 patients older than 45 who had dementia and lived in Olmsted County from 1985 to 1994. They compared that group to people of similar ages in Olmsted County who did not develop dementia during that time. Researchers found that about 70 percent of the patients in both groups needed surgery requiring general anesthesia - meaning those who had dementia and underwent surgery that included general anesthesia did not get worse, and those who did not have dementia and had surgery did not develop dementia as a result.


Mayo Clinic anesthesiologist Juraj Sprung, M.D., Ph.D., is the study’s first author. The study was funded by Mayo Clinic and the National Center for Advancing Translational Sciences.

About Mayo Clinic

Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life.

Journalists can become a member of the Mayo Clinic News Network for the latest health, science and research news and access to video, audio, text and graphic elements that can be downloaded or embedded.


Nick Hanson

.(JavaScript must be enabled to view this email address)
Mayo Clinic

Post a comment [ + Comment here + ]

There are no comments for this entry yet. [ + Comment here + ]

Your details

* Required field

Please enter the word you see in the image below:

Comments are moderated by our editors, so there may be a delay between submission and publication of your comment. Offensive or abusive comments will not be published.

What is dementia?

anterograde amnesia10 - restlessness1 - dopamine6 - development of alzheimer's1 - amyloid β1 - movement disorder2 - amyloid markers1 - inheritable dominant disease1 - blood pressure6 - neurotoxic oligomers1 - risk of alzheimer's3 - loss of balance1 - blast-induced traumatic brain injury1 - ad prognosis1 - degeneration theory1 - delta-9-tetrahydrocannabinol1 - high-cholesterol diet1 - esquirol1 - behavioral signs1 - blood sugar3 - diet control1 - protein alpha-synuclein1 - alzheimer's dementia2 - transcatheter aortic valve implantation2 - emotional lability1 - journal of the american geriatrics society1 - oxidative stress1 - kahlbaum3 - alzheimer's agitation1 - risperidone2 -