Dementia Today.net

Site updated at Wednesday, 22 June 2016

Living with Dementia

Amyloid Beta

Alzheimer’s missing link found

Yale School of Medicine researchers have discovered a protein that is the missing link in the complicated chain of events that lead to Alzheimer’s disease, they report in the Sept. 4 issue of the journal Neuron. Researchers also found that blocking the protein with an existing drug can restore memory in mice with brain… Alzheimer’s missing link found   



Uncovering first molecular missteps that drive neurons in pathway leading to Alzheimer’s disease

Much of the debate in Alzheimer’s disease (AD) has focused on whether the protein amyloid-beta or the tau protein is the symptom or the cause of the disease.

But George Bloom, Ph.D., and colleagues at the University of Virginia (UVA) have pursued another hypothesis: much earlier interactions between the two proteins them drive adult… Uncovering first molecular missteps that drive neurons in pathway leading to Alzheimer’s disease   



Uncovering first molecular missteps that drive neurons in pathway leading to Alzheimer’s disease

Much of the debate in Alzheimer’s disease (AD) has focused on whether the protein amyloid-beta or the tau protein is the symptom or the cause of the disease.

But George Bloom, Ph.D., and colleagues at the University of Virginia (UVA) have pursued another hypothesis: much earlier interactions between the two proteins them drive adult… Uncovering first molecular missteps that drive neurons in pathway leading to Alzheimer’s disease   



Molecular modeling of novel potent agents for treating Alzheimer’s disease

Alzheimer’s disease (AD), a severe form of dementia among aged individuals, is caused by accumulation of amyloid-beta (Aβ) peptides in the brain. Numerous types of agents have been developed to suppress the production of Aβ, by inhibiting the secretase-mediated cleavage of amyloid precursor protein (APP) into Aβ peptides.

However, because the secretases also play… Molecular modeling of novel potent agents for treating Alzheimer’s disease   



Enid and George - Life with dementia

cholesterol-lowering drugs1 - general activity1 - moderate intensity aerobic exercise1 - parkinsons diagnosis1 - brain injury1 - neuroscience2 - cognitive tests1 - short-term memory problems1 - huntington's disease8 - diagnose parkinson's1 - rates of dementia1 - ptau1 - living with dementia1 - alzheimers society2 - brain imaging1 - alzheimer’s vaccine1 - amyloid plaques13 - failing memory1 - symptoms of dementia3 - cognitive deficits1 - sleep loss1 - alzheimer's treatment3 - preparing for appointment1 - memory disorders program1 - igf resistance1 - mental exercises1 - sleep-disordered breathing1 - mental function1 - tetrahydrocannabinol1 - atypical alzheimer disease1 -