Dementia Today.net

Site updated at Wednesday, 22 June 2016

Living with Dementia

Amyloid Beta

Alzheimer’s missing link found

Yale School of Medicine researchers have discovered a protein that is the missing link in the complicated chain of events that lead to Alzheimer’s disease, they report in the Sept. 4 issue of the journal Neuron. Researchers also found that blocking the protein with an existing drug can restore memory in mice with brain… Alzheimer’s missing link found   



Uncovering first molecular missteps that drive neurons in pathway leading to Alzheimer’s disease

Much of the debate in Alzheimer’s disease (AD) has focused on whether the protein amyloid-beta or the tau protein is the symptom or the cause of the disease.

But George Bloom, Ph.D., and colleagues at the University of Virginia (UVA) have pursued another hypothesis: much earlier interactions between the two proteins them drive adult… Uncovering first molecular missteps that drive neurons in pathway leading to Alzheimer’s disease   



Uncovering first molecular missteps that drive neurons in pathway leading to Alzheimer’s disease

Much of the debate in Alzheimer’s disease (AD) has focused on whether the protein amyloid-beta or the tau protein is the symptom or the cause of the disease.

But George Bloom, Ph.D., and colleagues at the University of Virginia (UVA) have pursued another hypothesis: much earlier interactions between the two proteins them drive adult… Uncovering first molecular missteps that drive neurons in pathway leading to Alzheimer’s disease   



Molecular modeling of novel potent agents for treating Alzheimer’s disease

Alzheimer’s disease (AD), a severe form of dementia among aged individuals, is caused by accumulation of amyloid-beta (Aβ) peptides in the brain. Numerous types of agents have been developed to suppress the production of Aβ, by inhibiting the secretase-mediated cleavage of amyloid precursor protein (APP) into Aβ peptides.

However, because the secretases also play… Molecular modeling of novel potent agents for treating Alzheimer’s disease   



Parkinson’s Disease Dementia

a-beta protein1 - brain tissue1 - psychometrics1 - alzheimer's agitation1 - protein tau2 - fronto temporal lobar degeneration1 - cjd2 - neurofibrillary tangle1 - alzheimer's dementia2 - adam10 enzyme1 - irreversible dementia syndrome1 - apolipoprotein e2 - development of parkinson's1 - traumatic forms of dementia1 - deep-brain stimulation3 - undertreatment of dementia1 - antioxidants1 - language impairment1 - dimebon1 - signs of alzheimers1 - delirium tremens1 - mood changes1 - memory loss20 - protective effect1 - memory retrieval1 - beta-amyloid8 - temporal orientation1 - igf-11 - merck1 - vci1 -