Dementia Today.net

Site updated at Wednesday, 22 June 2016

Living with Dementia

Cognitive Decline

10 Warning Signs of Alzheimer’s and Dementia

How do you know if your parent has Alzheimer’s disease or dementia? If dad continually forgets where he puts his keys, or mom seems to get easily confused these days, does it mean they have Alzheimer’s? Not necessarily. Only a doctor can diagnose the condition. Every person experiences different symptoms, to different degrees. But… 10 Warning Signs of Alzheimer’s and Dementia   



A Guide to the Diagnosis and Assessment of Alzheimer’s Disease

DEFINITION OF THE DEMENTIA SYNDROME

The characteristic clinical feature of dementia is the presence of cognitive decline sufficient to cause functional impairment. Criteria for dementia are defined in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM IV). When dementia has been confirmed, the differential diagnosis can begin. The onset of progressive… A Guide to the Diagnosis and Assessment of Alzheimer’s Disease   



Differential diagnosis of dementia

Aging and cognitive decline

There is a natural age-associated modification in cognition. As a consequence, it can be problematic distinguishing between cognitive impairment associated with normal aging and early dementia. In addition, ‘mild cognitive impairment’ (MCI) can be experienced. This is characterized by an abnormal level of cognitive impairment, albeit that it does not… Differential diagnosis of dementia   



Diagnostic criteria for Alzheimer’s Disease

A number of criteria-based approaches to the diagnosis of AD have been developed. The three most commonly used are:

  * International Classification of Diseases, 10th revision (ICD-10)
  * Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM IV)
  * National Institute of Neurological and Communicative Disorders and Stroke… Diagnostic criteria for Alzheimer’s Disease   



Dementia’s First Signs Appear Long Before Old Age, Study Finds

The most unwelcome sign of aging, cognitive decline, may begin as young as 45, researchers found.

Scores on memory, reasoning and fluency tests fell starting in the mid-to-late 40s in a study of more than 7,000 U.K. government workers, said researchers led by Archana Singh-Manoux at France’s Centre for Research in Epidemiology and Population… Dementia’s First Signs Appear Long Before Old Age, Study Finds   



Blood Vessel Disease of Retina May be Marker of Cognitive Decline

Women 65 or older who have even mild retinopathy, a disease of blood vessels in the retina, are more likely to have cognitive decline and related vascular changes in the brain, according to a multi-institutional study led by scientists at the University of California, San Francisco (UCSF).

The findings suggest that a relatively simple… Blood Vessel Disease of Retina May be Marker of Cognitive Decline   



Hospitalization can speed cognitive decline in elderly

Hospitalization of older people might place them at higher risk for accelerated cognitive decline, according to a study released Wednesday.

Rates of decline occurred twice as fast among elderly patients on average after a hospital stay compared with their previous rate of decline and with older people not admitted to a health care facility.… Hospitalization can speed cognitive decline in elderly   



Eli Lilly Announces FDA Approval of Amyvid For Alzheimer’s Assessment

Eli Lilly and Company (NYSE: LLY) and Avid Radiopharmaceuticals, Inc., a wholly owned subsidiary of Lilly, today announced the U.S. Food and Drug Administration (FDA) approval of Amyvid™, a radioactive diagnostic agent indicated for brain imaging of beta-amyloid plaques in patients with cognitive impairment who are being evaluated for Alzheimer’s Disease and other causes… Eli Lilly Announces FDA Approval of Amyvid For Alzheimer’s Assessment   



FDA OKs Agent to Differentiate Alzheimer’s

The FDA has approved the radioactive diagnostic agent florbetapir (Amyvid) for evaluation of the causes of cognitive decline, including Alzheimer’s disease, according to Eli Lilly, developer of the compound.

Florbetapir is used in conjunction with positron emission tomography to evaluate the burden of amyloid plaques in the brain, according to Daniel Skovronsky, MD, PhD,… FDA OKs Agent to Differentiate Alzheimer’s   



Dementia Risk Seen in Study Refusers

People who declined to participate in a prospective study of aging developed dementia more quickly than those who joined the study, a researcher said here, suggesting study participants may not be a representative sample.

Among participants in the study, dementia was diagnosed at a rate of 19.1 per 1,000 person-years, compared with 23.6 per… Dementia Risk Seen in Study Refusers   



GMCSF treatment associated with improved cognition in cancer patients, USF-Moffitt study finds

Growth factors shown to cure Alzheimer’s disease in a mouse model and administered to cancer patients as part of their treatment regimen were linked to significant improvements in the patients’ cognitive function following stem cell transplantation, a preliminary clinical study reports.

The findings by researchers at the USF Health Byrd Alzheimer’s Institute and Moffitt… GMCSF treatment associated with improved cognition in cancer patients, USF-Moffitt study finds   



Link between brain insulin resistance, neuronal stress in worsening Alzheimer’s disease

Rhode Island Hospital researcher Suzanne de la Monte, M.D., has found a link between brain insulin resistance (diabetes) and two other key mediators of neuronal injury that help Alzheimer’s disease (AD) to propagate. The research found that once AD is established, therapeutic efforts must also work to reduce toxin production in the brain. The… Link between brain insulin resistance, neuronal stress in worsening Alzheimer’s disease   



Alzheimer’s cognitive decline slows in advanced age

The greatest risk factor for Alzheimer’s disease (AD) is advancing age. By age 85, the likelihood of developing the dreaded neurological disorder is roughly 50 percent. But researchers at the University of California, San Diego School of Medicine say AD hits hardest among the “younger elderly”  -  people in their 60s and 70s -… Alzheimer’s cognitive decline slows in advanced age   



Hearing loss may be related to cognitive decline in older adults

Hearing loss appears to be associated with accelerated cognitive decline and cognitive impairment in a study of older adults, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication.

The prevalence of dementia is projected to double every 20 years because of the world’s aging population so identifying the… Hearing loss may be related to cognitive decline in older adults   



Early genetic markers of Alzheimer’s risk identified

Genetic markers that could help highlight who is at risk of developing Alzheimer’s disease have been identified by US scientists.

The research in Neuron identifies mutations that affect the build-up of certain proteins in the brain.

High levels of these tau proteins increase the chance of having the disease.

UK experts said the study… Early genetic markers of Alzheimer’s risk identified   



Researchers Use Peanut Butter to Diagnose Alzheimer’s Disease

Florida researchers have come up with a novel way to help diagnose Alzheimer’s disease. They use peanut butter and a ruler.

These unusual tools provide a way for scientists to test subjects for smell sensitivity, according to ScienceDaily. In Alzheimer’s patients, one of the first locations in the brain to experience degeneration is… Researchers Use Peanut Butter to Diagnose Alzheimer’s Disease   



Poor sleep tied to Alzheimer’s-like brain changes

Older adults who don’t sleep well have more of the brain plaques that are hallmarks of Alzheimer’s disease, a new study suggests.

The finding doesn’t prove that not getting enough shut-eye causes the build-up of beta-amyloid plaques and leads to dementia rather than the other way around.

The researchers can’t be sure which came… Poor sleep tied to Alzheimer’s-like brain changes   



Recessions experienced in mid-life linked to higher risk of cognitive decline later on

Lay-offs and enforced part time work and lower paid, lower status jobs (downward job mobility), sparked by recessions, may explain the toll taken on cognitive ability - memory, verbal fluency, temporal orientation, and numeracy - the findings suggest.

Previous research suggests that working conditions may influence the potential to build up “cognitive reserve,” which… Recessions experienced in mid-life linked to higher risk of cognitive decline later on   



Blood test identifies those at-risk for cognitive decline, Alzheimer’s within 3 years

Researchers have discovered and validated a blood test that can predict with greater than 90 percent accuracy if a healthy person will develop mild cognitive impairment or Alzheimer’s disease within three years.

Described in Nature Medicine published online today, the study heralds the potential for developing treatment strategies for Alzheimer’s at an earlier stage,… Blood test identifies those at-risk for cognitive decline, Alzheimer’s within 3 years   



Alzheimer’s Disease

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