Dementia Today.net

Site updated at Wednesday, 22 June 2016

Living with Dementia

Frontotemporal Dementia

UCLA scientists uncover potential target for treating common form of early-onset dementia

No cure exists for frontotemporal dementia, which strikes between the ages of 40 and 64 and accounts for at least one in four cases of early-onset dementia. Caused by the death of cells in the front and sides of the brain, the disease can lead to dramatic changes in a patient’s personality and behavior,… UCLA scientists uncover potential target for treating common form of early-onset dementia   



Gene for Lou Gehrig’s Disease and Frontotemporal Dementia Identified

Frontotemporal dementia and amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease -  two fatal neurodegenerative disease with distinct symptoms - are triggered by a common mutation in many cases, according to researchers who say they have identified the mutated gene.

In the study, reported in the September 21 online issue of Neuron,… Gene for Lou Gehrig’s Disease and Frontotemporal Dementia Identified   



Frontotemporal Dementia Seen in Elderly

Frontotemporal lobar degeneration, though not common, does exist in elderly patients and has different characteristics than the presenile-onset disease, researchers reported.

Over a 25-year period, so-called elderly FTLD accounted for 3.2% of dementia cases among older patients seen at a regional neuroscience center in England, according to Atik Baborie, MD, of the Walton Centre… Frontotemporal Dementia Seen in Elderly   



Identification of abnormal protein may help diagnose, treat ALS and frontotemporal dementia

Amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, and frontotemporal dementia (FTD) are devastating neurodegenerative diseases with no effective treatment. Researchers are beginning to recognize ALS and FTD as part of a spectrum disorder with overlapping symptoms. Now investigators reporting online February 12 in the Cell Press journal Neuron have discovered an abnormal protein… Identification of abnormal protein may help diagnose, treat ALS and frontotemporal dementia   



Cancer drug prevents build-up of toxic brain protein

Researchers at Georgetown University Medical Center have used tiny doses of a leukemia drug to halt accumulation of toxic proteins linked to Parkinson’s disease in the brains of mice. This finding provides the basis to plan a clinical trial in humans to study the effects.

They say their study, published online May 10 in… Cancer drug prevents build-up of toxic brain protein   



Protein that Causes Frontotemporal Dementia also Implicated in Alzheimer’s Disease

Researchers at the Gladstone Institutes have shown that low levels of the protein progranulin in the brain can increase the formation of amyloid-beta plaques (a hallmark of Alzheimer’s disease), cause neuroinflammation, and worsen memory deficits in a mouse model of this condition. Conversely, by using a gene therapy approach to elevate progranulin levels, scientists… Protein that Causes Frontotemporal Dementia also Implicated in Alzheimer’s Disease   



Frontotemporal Dementia Signs and Symptoms

People with FTD typically first come to the doctor’s office because of:

  Gradual and steady changes in behavior,
  Gradual and steady language dysfunction or
  Gradual and steady weakness or slowing of movement


Behavioral symptoms

Apathy is often the first symptom reported by caregivers and may be mistaken for depression.… Frontotemporal Dementia Signs and Symptoms   



Scientists create mice with a major genetic cause of ALS and FTD

Scientists at Mayo Clinic, Jacksonville, Florida created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease), both of which are caused by a mutation in the a gene called C9ORF72. The study was partially funded… Scientists create mice with a major genetic cause of ALS and FTD   



Living with dementia

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