Dementia Today.net

Site updated at Wednesday, 22 June 2016

Living with Dementia

Neurodegenerative Disorder

Inflammatory mediator enhances plaque formation in Alzheimer’s disease

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that causes progressive cognitive impairment and memory loss. Now, a new study published by Cell Press in the September 8 issue of the journal Neuron identifies a previously unrecognized link between neuroinflammation and the classical pathological brain changes that are the hallmark of the disease. In… Inflammatory mediator enhances plaque formation in Alzheimer’s disease   



Scripps Research Institute scientists help unravel central mystery of Alzheimer’s disease

Scientists at The Scripps Research Institute (TSRI) have shed light on one of the major toxic mechanisms of Alzheimer’s disease. The discoveries could lead to a much better understanding of the Alzheimer’s process and how to prevent it.

The findings, reported in the April 10, 2013 issue of the journal Neuron, show that brain… Scripps Research Institute scientists help unravel central mystery of Alzheimer’s disease   



Gene therapy bolsters enzyme activity to combat Alzheimer’s disease in mice

St. Jude Children’s Research Hospital scientists have identified an enzyme that can halt or possibly even reverse the build-up of toxic protein fragments known as plaques in the brains of mice with Alzheimer’s disease. The research appeared in a recent edition of the scientific journal Nature Communications.

Plaques decreased substantially in mice treated with… Gene therapy bolsters enzyme activity to combat Alzheimer’s disease in mice   



Protein that Causes Frontotemporal Dementia also Implicated in Alzheimer’s Disease

Researchers at the Gladstone Institutes have shown that low levels of the protein progranulin in the brain can increase the formation of amyloid-beta plaques (a hallmark of Alzheimer’s disease), cause neuroinflammation, and worsen memory deficits in a mouse model of this condition. Conversely, by using a gene therapy approach to elevate progranulin levels, scientists… Protein that Causes Frontotemporal Dementia also Implicated in Alzheimer’s Disease   



Alzheimer’s Disease

behavioral signs1 - amyloid-beta4 - memory disorder1 - alcoholic encephalopathy10 - amnestic mild cognitive impairment1 - play-up programme1 - mini-strokes2 - amyotrophic lateral sclerosis6 - motor deficits1 - amyloid beta protein2 - treatment for huntington disease1 - mixed dementia1 - risk factors1 - moderate dementia1 - hypomanic1 - treatment of alzheimer's disease1 - hyperlipidemia1 - slower overall movement1 - alzheimer's32 - alzheimer's changes2 - creutzfeldt-jakob disease5 - carotid ultrasound1 - insomnia2 - cajal-retzius cell1 - reversible dementia1 - downs syndrome1 - mirna1 - disease progression1 - memory retrieval1 - diabetes mellitus1 -