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What is Korsakoff’s Syndrome

  • - Dementia News
  • Feb 20, 2012
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Tags: | alcoholic encephalopathy | anterograde amnesia | encephalopathy-alcoholic | korsakoff psychosis |

The Korsakoff’s syndrome is a neurological disorder that is primarily caused by the decreased amount of vitamin B1 or thiamine in the person’s brain. This is also known as the Korsakoff’s psychosis and alcoholic encephalopathy. The condition is believed to be a result of alcohol abuse. Others identify the condition as the alcohol amnestic syndrome, meaning the condition is characterized by the loss of memory. Usually, the condition is preceded by Wernicke’s encelopathy, a form of neurological condition that is of the same mechanism as Korsakoff syndrome.

Those commonly affected of the condition are the middle-aged men to late adult men, ranging from 45 to 65 year of age. Those who misuse alcohol are believed to be affected. This is because of their long exposure to alcohol abuse that makes them prone to such syndrome. But those who have an unhealthy diet may also acquire the condition. In the United States, the condition is believed to cause about 1 to 3% of the total population. This would indicate that the homeless and the alcoholics are affected of such condition. Internationally, the condition would take about 2.8% max population in the world.

The condition can be diagnosed through psychological tests. A memory test can be done in order to diagnose the condition. But in order to diagnose the syndrome, they should be abstained from any alcohol intake to have a concrete medical diagnosis and that the withdrawal symptoms shall be disposed off.

Korsakoff’s Syndrome Symptoms

The symptoms of Korsakoff syndrome is influenced by the lack of thiamin in the body, that causes cerebral atrophy. The condition is characterized by three classical manifestations:

Eye involvement
The patient may experience involuntary year movements such as jerking and even paralysis.

Coordination is affected
The patient may have difficulty maintaining balance and even the ability to walk may be affected.

Mental difficulties
The patient shall be confused and would feel drowsy all the time.

In general, a patient suffering from Korsakoff syndrome shall experience the following symptoms:

Sergei Korsakoff (1854 - 1900), a Russian neuropsychiatrist, published in 1887 the first of several papers on a special form of psychic disorder which occurs in conjunction with peripheral neuritis. He mentioned as characteristic such symptoms as irritable weakness, rapid fatiguing, sleeplessness, memory disturbance, preoccupation with fantasy, and fearfulness. In its modern use the term ‘Korsakoff syndrome’ refers to a group of symptoms — known alternatively as the amnesic syndrome — which includes inattentiveness, memory defect for recent events, retrograde amnesia and other disorders of recall and recognition, and disorientation in time, place, and situation. Confabulation, grandiose ideas, and an inappropriate cheerfulness are prominent symptoms in some cases. The syndrome can occur without peripheral neuritis, for example as a stage in recovery after trauma to the brain. When it is combined with peripheral neuritis, the term ‘Korsakoff psychosis’ tends to be used.

The Korsakoff syndrome develops most often in chronic alcoholics who fail to take an adequate diet. This may cause an acute deficiency of thiamine (vitamin B1), which produces an acute delirious illness known as Wernicke’s encephalopathy. When or if the patient recovers he will probably be left with the typical features of the Korsakoff syndrome.

The syndrome has seized the interest of neurologists and psychologists because it throws light on normal processes of recall and recognition, although many of the questions it raises have yet to be given precise answers. The memory defect is revealed in the difficulty the patient shows in finding his way about, his forgetfulness in simple matters, and especially his failure to retain information. Also, presented with an object he has been shown a few minutes before, he tends to respond to it as not identical or as in some manner changed. A learning disability can readily be demonstrated in such tests as ‘paired associates’ and in the delayed recall of pictures of everyday objects. There is a tendency to persist in giving wrong answers, and to fail to ‘unlearn’. The deficiency in recalling recent events has been attributed to partial or total derangement of the consolidation of sensory impressions as a permanent memory trace, or engram, or, to put it another way, to a failure to transfer information from a short-term to a long-term memory store. Explanation along these lines has to be qualified by the observation that the patient sometimes recalls after a few hours what he has not recalled after a few minutes.

Personality changes
This is possible for he or she may show lack of concern and reaction from a stimulus or stimuli that requires some.

Maladaptive tendencies
The patient may have difficulty in getting new information and learning skills.

He or she may have difficulties in memory. Confabulation is described as filling in some memory gaps with different life events.

Delusion tendencies
This is why the condition is referred as Korsakoff psychosis for it results to some delusional tendencies of the client.

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